The single question most people arrive with is some version of "is this just a cramp?" It is a fair question, because the two really can feel similar at first. The difference tends to reveal itself in how the discomfort behaves over time and in the company it keeps.
A classic muscle cramp, the kind sometimes called a charley horse, usually arrives suddenly, grips hard for seconds to minutes, and then eases with stretching, gentle movement, or rest. It typically leaves nothing behind once it passes. A clot is more of a slow burn. Mayo Clinic's description of DVT points to pain that lingers, may worsen when you stand or walk, and travels with other signs such as swelling, warmth, or skin changes that a simple cramp does not produce.
The comparison below can help you sort one from the other, though it is a guide for your thinking rather than a way to diagnose yourself at home.
Plenty of leg pain has nothing to do with clots at all. Nerve-related pain from the lower back, for instance, can radiate down one leg and mimic other problems, which our overview of sciatica symptoms and treatment helps explain. The takeaway is not to diagnose the cause yourself, but to recognize when the cramp explanation no longer fits and a professional should weigh in.